|
KMID : 0604119990050030246
|
|
Journal of the Korean Society of Menopause
1999 Volume.5 No. 3 p.246 ~ p.254
|
|
|
The Effect of Antiestrogen (LY117018) and Antiprogesterone (RU486) on The Secretion of Follicle Stimulating Hormone (FSH) and mRNA Levels of FSHβ Subunit in Ovariectomized Rat
|
|
1이병석/1Byung Seok Lee
1정철완/1박기현/1조동제/1송찬호/2윤미정/2김창미/2유경자/1Chul Wan Jung/1Ki Hyun Park/1Dong Jae Cho/1Chan Ho Song/2Mi Jung Yoon/2Chang Mi Kim/2Kyung Ja Ryu
|
|
|
Abstract
|
|
|
Follicle stimulating hormone (FSH) consists of α and β subunits, which are encoded
by separate genes. Pituitary release of FSHβ appears to be regulated by the
hypothalamic GnRH and the gonadal steroid hormones. We already reported that
estradiol and progesterone reduce the secretion of FSH and FSHβ subunit mRNA at
the pretranslational level. However little is known about their regulation of the
biosynthesis of FSH subunits. In the present study, we injected antiestrogen and
antiprogesterone in order to know the role of gonadal steroid hormones in
ovariectomized rats. We also investigated that whether the inhibitory effect of
progesterone and estradiol on the secretion and mRNA subunit production of FSH is
mediated through naloxone, which is opioid receptor blocker, at the pretranslational
levels. It revealed that treatment of antiestrogen (LY117018) or antiprogesterone (RU
486) significantly reduced inhibitory effect of estradiol and progesterone on FSH
secretion. Furthermore, RU486 significantly restored α and FSHβsubunit mRNA levels
which was suppressed by the progesterone treatment. And opioid receptor blocker,
naloxone did not modulate and FSH subunit mRNA levels as well as FSH secretion in
ovariectomized rats. Therefore, we concluded that progesterone may regulate the FSHβ
subunit mRNA synthesis more prominently than estradiol, and the effect of progesterone
for the regulation of FSH secretion and FSH βsubunit mRNA may not be mediated by
endogenous opioid.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|